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ADD/ADHD

ADHD is a common behavioral disorder that affects about 10% of school-age children and can carry over into adulthood. Boys are about three times more likely than girls to be diagnosed with it, though it’s not yet understood why. Generation Diagnostics can analyze your child’s genes and help his or her healthcare provider select which medications are more likely to work better for your child and less likely to cause unwanted side effects. The good news is that with proper treatment, kids and adults with ADHD can learn to successfully live with and manage their symptoms.

ADHD, ADD, Narcolepsy Pharmacogenetic Test

Our test analyzes how patients’ genes affect their metabolism and possible response to FDA-approved medications commonly prescribed to treat ADHD. The information from this test can help you select the medication(s) and dose(s) that are better suited to your patient’s condition and genetic profile.

Generation Diagnostics provides an objective and personalized approach to treatment.

Our test is based on pharmacogenomics – the study of how genes affect a person’s response to medicines.

Adiponectin (Genetic risk for decreased)

Description:  Adiponectin is a hormone that is produced by fat cells and functions in the body to trigger liver and muscles to get energy from fat. Higher levels of adiponectin are considered good for weight loss and health. Of note, Adiponectin levels can be monitored medical providers to better understand a patient’s levels.

Aminoglycoside-Induced Hearing Loss

Description:  Aminoglycoside antibiotics such as streptomycin, gentamicin, neomycin, paromomycin, kanamycin, spectinomycin, amikacin, netilmicin and tobramycin have been widely used to treat bacterial infection. However, aminoglycoside use also carries the risk of both damage to the kidneys or ears; this risk is increased further in individuals carrying certain genetic variants.

Amniocentesis

With amniocentesis, a small amount of amniotic fluid is withdrawn from the amniotic sac surrounding the fetus in the uterus. Chromosome analysis is performed on the fetal cells to provide crucial information about the health of the child.

Analgesic

Everybody responds differently to FDA-approved medication. The information from our test can help your healthcare provider select the medicine(s) and dose(s) that work best for your particular genetic makeup. Taking the correct medicine and dosage will make you feel better with fewer side effects. Our test analyzes how your genes affect the way your body may respond to FDA-approved medicines commonly prescribed to treat acute or chronic pain. The information from our test can help your healthcare provider select the medicine(s) and dose(s) that are best suited to your condition and genetic makeup. Medicines that align well with your genes may work better with fewer side effects.

The test gives clinicians a multi-gene pharmacogenomics tool to guide medication decisions for patients’ own genetic profiles to help determine their potential response to 22 medications across four relevant medication classes: opioids, NSAIDs, muscle relaxants, and opioid dependency.

Attorney Referral Program

We work with attorneys around the state of Texas who have partnered with us in spreading the word about the importance of DNA Testing. Although it’s a necessity in some situations, it’s an important test which should be done at only the most reliable, discreet, and convenient locations. Our full service lab and clinic located in Houston can run all of your genetic testing needs including Paternity and Immigration tests. Both legal and non-legal are available. We work with the majority of consulates and are AABB certified and accredited.

 

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Blood Pressure Response to Exercise

Description: High blood pressure, also known as hypertension, is a common but serious health issue. A specific genetic marker has been shown to increase the likelihood of hypertension in people who were low in cardiorespiratory fitness, which refers to the ability of the heart and lungs to provide muscles with oxygen for physical activity.

BMI Response to Exercise

Description:  Body mass index (BMI) is a number expressing the height to weight ratio. A specific genetic marker has been shown to be associated with increased BMI and waistline. However, people who have this genetic variant could reduce their propensity to increased BMI by staying physically active.

Breast Cancer Testing

You will work with a genetic counselor who will guide your through the process and help you interpret the results. First, you will be asked to create a family chart to see if there is a pattern of breast cancer within your family. Next, a blood test will be performed to see if you carry a mutation in a gene linked to cancer predisposition. Scientists do not know every mutation associated with particular cancers, so you will only be tested for mutations in known genes — particularly BRCA1 and BRCA2. Other members of your family may be asked to participate by offering a sample of blood. If you decide testing is the right thing to do, risk screening can be done for women and men as early as age 19 – and at any age after that.

Blog

Generation Diagnostics and Center for Medical Genetics are proud to offer a regularly updated website with new material and regularly updated blog.

 

BRCA1

People who have the breast cancer 1 or 2 mutation have a greatly increased chance of cancer. These inherited mutations are called BRCA1 and BRCA2. Other gene mutations (53, CHECK2, ATM) may also be linked to breast cancer. These known mutations account for only 5-10 percent of breast cancers diagnosed in the U.S. People with a mutation are referred to as “carriers.” It does not mean they will get cancer.

 

BRCA2

People who have the breast cancer 1 or 2 mutation have a greatly increased chance of cancer. These inherited mutations are called BRCA1 and BRCA2. Other gene mutations (53, CHECK2, ATM) may also be linked to breast cancer. These known mutations account for only 5-10 percent of breast cancers diagnosed in the U.S. People with a mutation are referred to as “carriers.” It does not mean they will get cancer.

 

Breast Cancer

A genetic mutation is a change in the genetic code that affects the functioning of that gene. These gene mutations can be passed on from parent to child. There are particular mutations that can increase risk for breast cancer. People who have the breast cancer 1 or 2 mutation have a greatly increased chance of cancer. These inherited mutations are called BRCA1 and BRCA2. Other gene mutations (53, CHECK2, ATM) may also be linked to breast cancer. These known mutations account for only 5-10 percent of breast cancers diagnosed in the U.S. People with a mutation are referred to as “carriers.” It does not mean they will get cancer. You will work with a genetic counselor who will guide your through the process and help you interpret the results. First, you will be asked to create a family chart to see if there is a pattern of breast cancer within your family. Next, a blood test will be performed to see if you carry a mutation in a gene linked to cancer predisposition. Scientists do not know every mutation associated with particular cancers, so you will only be tested for  mutations in known genes — particularly BRCA1 and BRCA2. Other members of your family may be asked to participate by offering a sample of blood. If you decide testing is the right thing to do, risk screening can be done for women and men as early as age 19 – and at any age after that.

 

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Cancer Testing

Mutations are common changes that occur in the DNA of all the cells of the human body. Most of the time cells can correct such changes. Sometimes however, a mutation (or a series of consecutive mutations) can cause cancer when it damages a distinct gene. There are specific genetic tests that detect mutations associated with distinct types of cancer (e.g. BRCA1 and BRCA2 in hereditary breast cancer). In certain situations, genetic testing for cancer risk and the study of the family history help to estimate the likelihood that an individual will develop cancer in his or her lifetime. The genetic test is done in a blood sample that is subsequently studied in the laboratory. The results are interpreted by a genetic counselor in conjunction with the family history and other medical information. Afterwards, the counselor will explain the implications for the family. It is important to understand however, that no test offers 100 percent of diagnostic certainty which means that it may not be able to identify a mutation. In addition, not everyone with a genetic predisposition will develop cancer.

Cancer Predisposition Testing

In certain situations, genetic testing for cancer risk and the study of the family history help to estimate the likelihood that an individual will develop cancer in his or her lifetime. The genetic test is done in a blood sample that is subsequently studied in the laboratory. The results are interpreted by a genetic counselor in conjunction with the family history and other medical information. Afterwards, the counselor will explain the implications for the family. It is important to understand however, that no test offers 100 percent of diagnostic certainty which means that it may not be able to identify a mutation. In addition, not everyone with a genetic predisposition will develop cancer.

Careers

Generation Diagnostics and Center for Medical Genetics are always hiring. Feel free to contact us through the Carriers Link.

Carrier Screening

Recent advances in genetics science have resulted in tests that can screen for a broad range of genetic diseases. A simple blood test is given. Results take around two weeks. You can take the test at any time, ideally before you become pregnant. A genetic disease or disorder is the result of changes, or mutations, in an individual’s DNA. Genetic diseases can be inherited because of mutations in the cells involved in passing genetic information from parents to offspring. In the past, people did not discover that they were a carrier for an inherited genetic disease until after they gave birth to a child with that disease. Generation Diagnostics offers Generation® Genetic Carrier Screening that can help you understand your chances of delivering a child with an inherited disease — even before you get pregnant.

Chromosomes

A thread like structure of nucleic acids and protein found in the nucleus of most living cells, carrying genetic information in the form of genes.

Chromosomal Conditions

If the test results are normal, you might not need further testing. However, if results indicate an increased risk that the fetus has a chromosomal abnormality, amniocentesis or CVS will be offered. Further testing using the sample from amniocentesis or CVS can be used to confirm the diagnosis.

Chromosome Microarray Analysis

Recent advances in genetics science have resulted in tests that can screen for a broad range of genetic diseases. A simple blood test is given. Results take around two weeks. You can take the test at any time, ideally before you become pregnant. A genetic disease or disorder is the result of changes, or mutations, in an individual’s DNA. Genetic diseases can be inherited because of mutations in the cells involved in passing genetic information from parents to offspring. In the past, people did not discover that they were a carrier for an inherited genetic disease until after they gave birth to a child with that disease. Generation Diagnostics offers Generation® Genetic Carrier Screening that can help you understand your chances of delivering a child with an inherited disease — even before you get pregnant.

Client Portal

Our client portal allows physicians, patients and clients easy access to reports and submitting information.

Clinic

We have four clinics in the state of Texas. They are located in Harlingen, Houston, Brownsville, and McAllen. You can find all of their information on the Contact Link.

Clopidogrel Metabolism (Plavix)

Description:  Clopidogrel is a medication used to inhibit the formation of blood clots in patients with coronary artery disease, peripheral vascular disease, and cerebrovascular disease.

Codeine and Nursing Mothers

Description:  Codeine is prescribed to relieve mild to moderately severe pain. Both genetic and non-genetic factors affect how the body processes / uses the medication. Dosage should always be carefully monitored if you are a breastfeeding mother that is considering using codeine as a pain reliever.

Contact

Feel free to contact us via our online contact form or by calling our office at 713-790-1990.

Cystic Fibrosis

A hereditary disorder affecting the exocrine glands. It causes the production of abnormally thick mucus, leading to the blockage of the pancreatic ducts, intestines, and bronchi and often resulting in respiratory infection.

Cystic Fibrosis Screening

Generation Diagnostics and the Center for Medical Genetics are proud to offer a cystic fibrosis screening. Patients should contact their healthcare provider about having this screening completed with us. Cystic fibrosis is a hereditary disorder affecting the exocrine glands. It causes the production of abnormally thick mucus, leading to the blockage of the pancreatic ducts, intestines, and bronchi and often resulting in respiratory infection.

 

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Dad Test

Generation® Dad Test™ DNA Identification testing is used by anyone needing the most accurate paternity test available for legal, personal or medical reasons, including:

  • A woman seeking child support
  • A man attempting to win child custody
  • Adoptive children seeking their biological families
  • Someone wanting to determine inheritance rights
  • Someone wanting to establish a medical history
  • Someone needingimmigration or citizenship determination

Diabetes, Type 1

Description: Type 1 Diabetes (T1D) is a chronic disease characterized by the destruction of beta cells in the pancreas. T1D is caused primarily by genetic factors that control the immune system and interact with environmental triggers.

Diabetes, Type 2

Description:  Type 2 diabetes (T2D) is a chronic disease in which there are high levels of sugar (glucose) in the blood, and is the most common form of diabetes. Individuals with T2D do not respond efficiently to insulin, the hormone responsible for regulating sugar levels in the body. The two most important risk factors for T2D are obesity and lack of physical activity. However, a number of genetic variants are associated with increased risks of developing T2D.

DNA

Deoxyribonucleic acid, a self-replicating material present in nearly all living organisms as the main constituent of chromosomes. It is the carrier of genetic information.

DNA Paternity

Paternity testing involves testing the DNA of both the potential father and child to see how compatible their test results are. If the potential father and child’s DNA are compatible on each segment of DNA examined, the probability that he is the biological father is typically over 99.99%. If there are any segments of DNA studied which do not match, the man is excluded as being the biological father. There is no more accurate testing method than the Dad Test™.

DNA Repair Genes

Fix any mistakes that might occur when the DNA makes a copy of itself. If there is an error in this gene, the mistake is not corrected and the gene becomes a mutation. Mutations in DNA repair genes can be acquired and inherited. (e.g. MLH1 and MSH2 – hereditary colon cancer)

DNA Testing

DNA Testing Law & Legal Definition. DNA (deoxyribonucleic acid) is the genetic blueprint that determines a person’s biological characteristics. DNA is located in the cell of the human body. One reason for DNA testing is to determine the paternity of a child.

Down Syndrome (Trisomy 21)

a congenital disorder arising from a chromosome defect, causing intellectual impairment and physical abnormalities including short stature and a broad facial profile. It arises from a defect involving chromosome 21, usually an extra copy (trisomy-21).

 

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Eating Disinhibition

Description: Eating disinhibition is a behavioral trait described as the inability to resist tempting food. Individuals with an increased risk of eating disinhibition may also have a tendency to eat foods that are high in fat, calories and carbohydrates, even if they are already full.

Endurance Training

Description:  Endurance training is generally used to describe exercise that is done for a longer duration with moderate intensity. Most people can benefit from a combination of endurance, high intensity and resistance exercises, but some individuals receive enhanced benefits from endurance training.

Estrogen Supplementation

Description:  Many oral contraceptives (birth control) and post-menopausal hormone replacement therapy products contain estrogen. These medications by themselves pose an increased risk of blood clots (i.e., venous thrombosis), but this risk is even greater when they are used by individuals with certain inherited risk factors for blood clotting disorders.

 

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Fetal DNA

Cell-free fetal DNA (DNA) is fetal DNA circulating freely in the maternal blood stream. It can be sampled by venipuncture on the mother. Analysis of of DNA provides a method of non-invasive prenatal diagnosis. Cell free fetal DNA shedding into maternal bloodstream.

Fetal rhesus (Rh)

Rhesus (Rh) factor is an inherited protein found on the surface of red blood cells. If your blood has the protein, you’re Rh positive. If your blood lacks the protein, you’re Rh negative.

Rh positive is the most common blood type. Having an Rh negative blood type is not an illness and usually does not affect your health. However, it can affect your pregnancy. Your pregnancy needs special care if you’re Rh negative and your baby’s father is Rh positive.

Your health care provider will recommend an Rh factor test during your first prenatal visit. This test will identify your blood type and whether your blood cells carry the Rh factor protein.

Fetal Sex

If you’re the carrier of an X-linked recessive disorder and the test results indicate that you’re carrying a girl, you might not need further testing. If the test results indicate that you’re carrying a boy, amniocentesis or CVS might be offered for further evaluation. In most situations, these tests can be used to diagnose a genetic disorder linked to the X-chromosome.

First Trimester Prenatal Screening

The Center for Medical Genetics and Generation Diagnostics are proud to offer the First Trimester Screen. The First Trimester Screen is a new, optional non-invasive evaluation that combines a maternal blood screening test with an ultrasound evaluation of the fetus to identify risk for specific chromosomal abnormalities, including Down Syndrome Trisomy-21and Trisomy-18.

In addition to screening for these abnormalities, a portion of the test (known as the nuchal translucency) can assist in identifying other significant fetal abnormalities, such as cardiac disorders.  The screening test does not detect neural tube defects. The first trimester screen has been available in the U.S. for several years, but has only recently been determined an effective means of early chromosomal abnormality screening. A study published in the New England Journal of Medicine in November 2005 determined that first trimester screening was the most accurate non-invasive screening method available.

The combined accuracy rate for the screen to detect the chromosomal abnormalities mentioned above is approximately 85% with a false positive rate of 5%.

Fit and Trim Test

Here at the Center for Medical Genetics and Generation Diagnostics we have developed a weight loss program that not only enables you to take the Generation Fit and Trim® DNA test to discover how your genes interact with your food and fitness, but also allows you one on one consultations with a genetic counselor and physician. The plan includes:

  • Initial consultation with a physician or genetic counselor.
  • Generation Fit and Trim® DNA test – which is done with a simple saliva sample.
  • Prescribed medication if needed and pharmacogenetic test to learn how your genes will interact with future medications you may take or are currently taking.
  • Follow up appointment to discuss results and get customized nutrition and fitness plan based on Generation Fit and Trim® DNA test results.
  • Weekly check-ins to monitor progress.

For patients without insurance we offer a financial assistance program. Please contact our Billing department for more information.

Folate (Genetic Risk for Decreased)

Description: Folate is important in maintaining life’s building blocks: DNA and proteins. Folate is present naturally from food or consumed as a synthetic supplement as folic acid. A healthy diet will typically provide sufficient folate, though people with problems absorbing folate, pregnant women, or people with a genetic variant may have increased risk of folate deficiency.

Food Desire

Description: Food desire is a way to describe the additional effort one may put forth to obtain one’s favorite foods. Individuals with increased food desire demonstrate an increased willingness and effort to obtain their favorite foods as well as eat more of them.

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Generation Dad Test

Generation® Dad Test™ DNA Identification testing is used by anyone needing the most accurate paternity test available for legal, personal or medical reasons, including:

  • A woman seeking child support
  • A man attempting to win child custody
  • Adoptive children seeking their biological families
  • Someone wanting to determine inheritance rights
  • Someone wanting to establish a medical history
  • Someone needingimmigration or citizenship determination

Generation Fit and Trim

Here at the Center for Medical Genetics and Generation Diagnostics we have developed a weight loss program that not only enables you to take the Generation Fit and Trim® DNA test to discover how your genes interact with your food and fitness, but also allows you one on one consultations with a genetic counselor and physician. The plan includes:

  • Initial consultation with a physician or genetic counselor.
  • Generation Fit and Trim® DNA test – which is done with a simple saliva sample.
  • Prescribed medication if needed and pharmacogenetic test to learn how your genes will interact with future medications you may take or are currently taking.
  • Follow up appointment to discuss results and get customized nutrition and fitness plan based on Generation Fit and Trim® DNA test results.
  • Weekly check-ins to monitor progress.

For patients without insurance we offer a financial assistance program. Please contact our Billing department for more information.

 

Generation Immigration Testing

Commonly tested relationships that utilize DNA testing include paternity, maternity, full-siblingship, or half-siblingship. More distant relationships cannot be proven reliably using DNA testing. DNA technology is the only non-documentary method accepted for proof of a biological relationship.

Generation Jack or Jill Gender Determination

The presence of fetal genetic material in the mother’s blood has made it possible to offer a non-invasive prenatal diagnosis to determine the gender of the baby. Since it is non-invasive, there are no risks to the mother or the fetus. The non-invasive approach is seeking Y chromosome-specific DNA in the maternal blood sample. After seven to ten days, you will be contacted with the results. PRESENCE of the  Y-chromosome confirms the presence of a male fetus. An ABSENCE of the Y-chromosome indicates a female fetus. In rare situations (prior to 11 weeks) there is insufficient fetal DNA in the blood which will trigger an inconclusive or non-reportable result.

Generation Genetic Carrier Screening

Recent advances in genetics science have resulted in tests that can screen for a broad range of genetic diseases. A simple blood test is given. Results take around two weeks. You can take the test at any time, ideally before you become pregnant. A genetic disease or disorder is the result of changes, or mutations, in an individual’s DNA. Genetic diseases can be inherited because of mutations in the cells involved in passing genetic information from parents to offspring. In the past, people did not discover that they were a carrier for an inherited genetic disease until after they gave birth to a child with that disease. Generation Diagnostics offers Generation® Genetic Carrier Screening that can help you understand your chances of delivering a child with an inherited disease — even before you get pregnant.

Genes

Individual genes are formed from patterns of DNA. These are the instructions located in our cells that direct how our bodies grow and develop. Genes come in pairs − one copy from your mother and one copy from your father. One gene might be normal and the other might have a mutation. In most cases, you would be healthy, but also a carrier of the genetic mutation. If both copies of the gene are affected, you would likely show disease symptoms.

Genetic Carrier Screening

Recent advances in genetics science have resulted in tests that can screen for a broad range of genetic diseases. A simple blood test is given. Results take around two weeks. You can take the test at any time, ideally before you become pregnant. A genetic disease or disorder is the result of changes, or mutations, in an individual’s DNA. Genetic diseases can be inherited because of mutations in the cells involved in passing genetic information from parents to offspring. In the past, people did not discover that they were a carrier for an inherited genetic disease until after they gave birth to a child with that disease. Generation Diagnostics offers Generation® Genetic Carrier Screening that can help you understand your chances of delivering a child with an inherited disease — even before you get pregnant.

Genetic Counselor

Meet with one of our genetic counselors to discuss you and your family’s health care needs. Genetic counselors work as members of a health care team and act as a patient advocate as well as a genetic resource to physicians. Genetic counselors provide information and support to families who have members with birth defects or genetic disorders, and to families who may be at risk for a variety of inherited conditions. They identify families at risk, investigate the problems present in the family, interpret information about the disorder, analyze inheritance patterns and risks of recurrence, and review available genetic testing options with the family. Genetic counselors are present at high risk or specialty prenatal clinics that offer prenatal diagnosis, pediatric care centers, and adult genetic centers. Genetic counseling can occur before conception (i.e. when one or two of the parents are carriers of a certain trait) through to adulthood (for adult onset genetic conditions, such as Huntington’s disease hereditary cancer syndromes).

Genetic Disease

A genetic disease or disorder is the result of changes, or mutations, in an individual’s DNA. Genetic diseases can be inherited because of mutations in the cells involved in passing genetic information from parents to offspring.

Genetic Risk for Decreased Vitamin A

Description:  Vitamin A is made from beta-carotene in the body. A healthy diet will typically provide sufficient beta-carotene. However, people with problems absorbing beta-carotene or people with certain genetic variants may have increased risk of vitamin A deficiency due to decreased ability in converting beta-carotene to vitamin A.

Genetic Risk due to Decreased Vitamin B2

Description:  Vitamin B2 is a central component for energy production and in the metabolism of carbohydrates, fats and proteins. A healthy diet will typically provide sufficient vitamin B2, though people with problems absorbing vitamin B2 or people with a genetic variant may have increased risk of vitamin B2 deficiency.

Genetic Risk for Decreased Vitamin B6

Description:  Vitamin B6 helps the body’s neurological system to function properly and to produce antibodies that help to fight off disease. A healthy diet will typically provide sufficient vitamin B6, though people with problems absorbing vitamin B6 or people with a genetic variant may have increased risk of vitamin B6 deficiency.

Genetic Risk for Decreased Vitamin B12

Description:  Vitamin B12 helps to keep red blood cells healthy and is a critical component for synthesis of DNA. A healthy diet will typically provide sufficient B12 vitamins, though vegetarians, vegans, people with problems absorbing B12 or people with a genetic variant may have increased risk of vitamin B12 deficiency.

Genetic Risk for Decreased Vitamin C

Description:  Vitamin C must be acquired from dietary sources, as humans are unable to synthesize it. While a severe deficiency of vitamin C ultimately leads to scurvy, variations in vitamin C levels have also been associated with a wide range of chronic complex diseases, such as atherosclerosis, type 2 diabetes and cancer. A healthy diet will typically provide sufficient vitamin C, though people with problems absorbing vitamin C or people with a genetic variant may have increased risk of vitamin C deficiency.

Genetic Risk for Decreased Vitamin D

Description:  Vitamin D is important for the absorption of calcium, which is beneficial to bones and muscles. A healthy diet with adequate exposure to sunlight will typically provide sufficient vitamin D, though people with problems absorbing vitamin D or people with a genetic variant may have increased risk of vitamin D deficiency.

Genetic Risk for Decreased Vitamin E

Description:  Vitamin E is important for a strong immune system and healthy skin. A healthy diet will typically provide sufficient vitamin E, though people with problems absorbing vitamin E or people with a genetic variant may have increased risk of vitamin E deficiency.

Genetic Mutation

A genetic mutation is a change in the genetic code that affects the functioning of that gene. These gene mutations can be passed on from parent to child. There are particular mutations that can increase risk for breast cancer.

Genetics Testing

Genetic testing is a type of medical test that identifies changes in chromosomes, genes, or proteins. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person’s chance of developing or passing on a genetic disorder.

 

H

HDL (Good) Cholesterol Response to Exercise

Description:  One of the health benefits of exercise is the improvement of the cholesterol levels. HDL cholesterol is known as the good cholesterol, and having more HDL is beneficial.

Genetic Risk for Decreased HDL Cholesterol

Description:  High-density lipoprotein (HDL) cholesterol is known as good cholesterol, because high levels of HDL cholesterol seem to protect against heart attack, while low levels of HDL cholesterol increase the risk of heart disease. HDL cholesterol levels can be monitored by a medical professional.

 

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Immigration Testing

DNA testing is invaluable for citizens and permanent residents who wish to sponsor relatives but lack birth certificates or other documents to prove the family relationship.

Inherited Genetic Disorders

Some couples may be carriers of genetic disorders for which prenatal diagnosis can be performed. Carrier testing and prenatal diagnosis are available for many disorders.

Insulin Sensitivity Response to Exercise

Description:  Insulin sensitivity is beneficial since insulin helps control response to glucose or sugar. Having an increased insulin sensitivity means that the body has a better ability to process sugar. The opposite of insulin sensitivity is called insulin resistance, which is linked to obesity and type 2 diabetes.

 

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Jack or Jill Early Gender Test

The presence of fetal genetic material in the mother’s blood has made it possible to offer a non-invasive prenatal diagnosis to determine the gender of the baby. Since it is non-invasive, there are no risks to the mother or the fetus. The non-invasive approach is seeking Y chromosome-specific DNA in the maternal blood sample. After seven to ten days, you will be contacted with the results. PRESENCE of the  Y-chromosome confirms the presence of a male fetus. An ABSENCE of the Y-chromosome indicates a female fetus. In rare situations (prior to 11 weeks) there is insufficient fetal DNA in the blood which will trigger an inconclusive or non-reportable result.

Jewish Diseases Genetic Testing

There are a number of genetic disease for which persons of Jewish heritage (at least one grandparent) are more likely to be carriers of than the general population. Carriers are healthy individuals, unaffected by the disease for which they carry. If both parents are carriers of a gene mutation for the same condition, there is a 25% chance, with each pregnancy, of having an affected child. These diseases are all serious and can be fatal and or life altering to children born with them.

 

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LDL Cholesterol (Genetic Risk for Elevated)

Description:  Low-density lipoprotein (LDL) is the type of cholesterol that can become dangerous if there is too much of it. LDL cholesterol can form plaque and build up in the artery walls, and in turn increases the risk of a heart attack or stroke. Cholesterol levels can be monitored by a medical professional.

Legal Testing

Different people have different needs. That’s why we offer different services so that you can decide what is best for your situation.

Legally conclusive DNA Identification means that a strict chain-of -custody is maintained to ensure the admissibility of the results in a court of law. All parties are positively identified and photographed at a collection facility. All testing is performed in a secured and monitored facility under the highest standards of quality control. Every report is double-checked and verified before sending the results.

Completely confidential DNA Identification can be chosen when you do not anticipate needing to use this information in a court of law. A kit can be mailed to you, so that the samples may be collected by you in the privacy of your own home. Because the samples are not collected at a collection facility, the test result is labeled as a completely confidential collection, and may not be admissible in a court of law. If peace of mind is your main concern, than this test may be right for you.

Regardless of how the samples were collected whether legally conclusive or completely confidential self-collection kit, the same high laboratory testing standards are used for all tests performed.

 

Loss of Body Fat Response to Exercise

Description:  Many people exercise to lose body fat. A specific genetic marker has been shown to increase the benefit of exercise to lose body fat.

 

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Matching Diet Type

Description:  An individual’s genetic profile can affect their responses to specific diet types. Based on individuals’ genetic makeup, they can be matched to one of four specific diet types: Low Fat, Low Carb, Mediterranean, or Balanced Diet. The recommended diet also takes into account the genetic risks for metabolic health factors.

Metabolism

Description:  Metabolism describes the way the body burns energy (calories) and tends to have a strong correlation to managing weight. Resting metabolism refers to how the body burns energy while at rest. People with a “Fast” resting metabolism can sometimes eat more food with little exercise and not gain weight, while people with a “Normal” resting metabolism tend to require average amounts of food intake and average amounts of exercise to maintain weight.

Methotrexate Toxicity

Description:  Methotrexate (MTX) is a medication indicated to treat lymphoma and leukemia, as well as other cancers. In addition, MTX is used in the treatment of psoriasis, rheumatoid arthritis and some inflammatory diseases. Some patients taking MTX may experience severe side effects, which are often referred to as MTX toxicity.

Monounsaturated Fats (Response to)

Description:  Fat is an important part of any diet, and not all fats are bad. Monounsaturated fat is considered a healthy dietary fat, and some individuals receive increased benefit from eating foods containing monounsaturated fats.

Mutation

A genetic mutation is a change in the genetic code that affects the functioning of that gene. These gene mutations can be passed on from parent to child. There are particular mutations that can increase risk for breast cancer.

 

 

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Non-Invasive Prenatal Testing (NIPT)

Generation® Non-Invasive Prenatal Screening is much more sensitive and specific than traditional first and second trimester screening, such as the first trimester screening and the quad screen. As a result, Generation® Non-Invasive Prenatal Screening can often help women who have certain risk factors avoid invasive testing that carries a slight risk of miscarriage, including amniocentesis and chorionic villus sampling (CVS).

NIPT (Non-Invasive Prenatal Testing)

Generation® Non-Invasive Prenatal Screening is much more sensitive and specific than traditional first and second trimester screening, such as the first trimester screening and the quad screen. As a result, Generation® Non-Invasive Prenatal Screening can often help women who have certain risk factors avoid invasive testing that carries a slight risk of miscarriage, including amniocentesis and chorionic villus sampling (CVS).

Non-Legal Testing

Different people have different needs. That’s why we offer different services so that you can decide what is best for your situation.

Legally conclusive DNA Identification means that a strict chain-of -custody is maintained to ensure the admissibility of the results in a court of law. All parties are positively identified and photographed at a collection facility. All testing is performed in a secured and monitored facility under the highest standards of quality control. Every report is double-checked and verified before sending the results.

Completely confidential DNA Identification can be chosen when you do not anticipate needing to use this information in a court of law. A kit can be mailed to you, so that the samples may be collected by you in the privacy of your own home. Because the samples are not collected at a collection facility, the test result is labeled as a completely confidential collection, and may not be admissible in a court of law. If peace of mind is your main concern, than this test may be right for you.

Regardless of how the samples were collected whether legally conclusive or completely confidential self-collection kit, the same high laboratory testing standards are used for all tests performed.

 

O

Obesity

Description:  Obesity is influenced by both genetic and environmental factors. Genetic factors are likely to be involved when an individual reaches a body mass index (BMI) of 30 to 35 (clinically obese) or above 40 (morbidly obese).

Omega-6 and Omega-3 (Genetic Risk for Decreased)

Description:  Polyunsaturated fats (PUFAs) in our diet are composed of omega-3 and omega-6 fatty acids, both of which are recommended by the American Heart Association (AHA) for good heart health. Both omega-3 and omega-6 fats are processed in the body by the same enzyme complex.

Oncogenes

Turn a healthy cell into a cancerous cell. These mutations are acquired and not inherited. (e.g. RET-hereditary thyroid cancer)

Open Spine and/or Open Skull Defects

About 99% of these defects may be detected using ultrasound examination and by testing for alpha-fetoprotein (AFP) and acetylcholinesterase (AChE), the fetal proteins in the amniotic fluid.

Osteoarthritis

Description:  Osteoarthritis (OA) is a common joint disorder, which is due to aging and wear and tear on the joints. Genetics, age, estrogen use and bone density are all important systemic risk factors for OA. Additionally, Obesity, joint injury, joint deformity, repetitive stress injuries, playing sports and muscle weakness affect the location and severity of OA.

 

P

Paternity

Paternity testing involves testing the DNA of both the potential father and child to see how compatible their test results are. If the potential father and child’s DNA are compatible on each segment of DNA examined, the probability that he is the biological father is typically over 99.99%. If there are any segments of DNA studied which do not match, the man is excluded as being the biological father. There is no more accurate testing method than the Dad Test™.

Paternity Testing

Paternity testing uses DNA identification to legally establish who the father is. For a relative seeking a visa, DNA testing offers biological proof of status.  Most importantly, DNA testing offers physical, emotional, and financial benefits that can only come from certainty.

Pharmacogenetics

The brand of pharmacology concerned with the effect of genetic factors on reactions to drugs.

Physicians

A person qualified to practice medicine.

Polyunsaturated Fats (Response to)

Description: Polyunsaturated fat is considered a healthy fat and is important for heart and brain function, as well as growth and development. Two types of polyunsaturated fats are omega-6 and omega-3 fats. Some individuals receive increased benefit from eating foods containing polyunsaturated fats.

Predisposition Testing

In certain situations, genetic testing for cancer risk and the study of the family history help to estimate the likelihood that an individual will develop cancer in his or her lifetime. The genetic test is done in a blood sample that is subsequently studied in the laboratory. The results are interpreted by a genetic counselor in conjunction with the family history and other medical information. Afterwards, the counselor will explain the implications for the family. It is important to understand however, that no test offers 100 percent of diagnostic certainty which means that it may not be able to identify a mutation. In addition, not everyone with a genetic predisposition will develop cancer.

Pregnancy Care

Our caring team of professionals continuously strives to provide our patients with the most comprehensive and accurate genetic testing services available. We offer a full range of technically advanced services including Ultra-Screen™, the revolutionary first trimester serum screening test that provides reassurance of a healthy, happy pregnancy earlier than any other test available. Dad Test™, our DNA paternity testing service, can conclusively prove or disprove parentage for legal, personal or medical reasons. Whether you want to ensure a healthy pregnancy, need a DNA identification test, or simply wish to access the absolute latest technology in genetic testing, we are here to help you. Some tests may be ordered directly, while others require the professional services from our team of highly skilled physicians or genetic counselors. Call us today and let us know how we may help you further.

Pregnancy Loss Genetic Evaluation

Pregnancy loss is very common, with up to 15% of recognized pregnancies resulting in miscarriage, usually in the first trimester. The Center for Medical Genetics offers genetic evaluation to study pregnancy loss, giving people insight into possible causes and providing them with the information they need to make informed family planning decisions from treatments to help carry a pregnancy to term to alternative options including egg or sperm donation, surrogacy, or adoption.

 

Prenatal

Before birth; during or relating to pregnancy.

Prenatal Testing

Methods for prenatal diagnosis include ultrasound of the uterus, placenta, and/or developing fetus; chorionic villus sampling (CVS) to obtain tissue for chromosome or biochemical analysis; and amniocentesis to obtain amniotic fluid for the analysis of chromosomes, enzymes, or DNA.

Psychotropic

Our Generation® Psychotropic tests evaluate your individual genetic code to see how you metabolize medications, as well as how you will respond to it. How you metabolize medication means you may need a different dosage or different type of medication to get the results you want. Using our test’s information, your physician can more confidently prescribe the right medicine and dosage for you.

 

R

Risks

Generation® Non-Invasive Prenatal Screening poses no physical risks for you or your baby.

While Generation® Non-Invasive Prenatal Screening might cause anxiety, it might help you avoid the need for more invasive tests, treatment or monitoring during your pregnancy.

Keep in mind, however, that Generation® Non-Invasive Prenatal Screening doesn’t screen for all chromosomal or genetic conditions. A negative test result does not ensure an unaffected pregnancy.

Rh factor

If you’re Rh negative and the test results indicate that the fetus is Rh negative, you won’t need medication to prevent your body from producing Rh antibodies during your pregnancy. If the test results indicate that the fetus is Rh positive and you’ve previously become sensitized, your baby will be carefully monitored.

 

 

S

Satiety (feeling full)

Description:  Satiety is the feeling of fullness after food consumption. Some people do not feel full after eating, which can lead to eating too much and not truly feeling satisfied.

Second Trimester Prenatal Screening

The second trimester screen is a prenatal test that measures levels of four substances in a pregnant woman’s blood: Alpha-fetoprotein (AFP), a protein made by the developing baby.

Sex Chromosome Aneuploidy

The term Klinefelter syndrome (KS) describes a group of chromosomal disorder in which there is at least one extra X chromosome to a normal male karyotype, 46,XY. XXY aneuploidy is the most common disorder of sex chromosomes in humans, with prevalence of one in 500 males.

Simvastatin-Induced Myopathy

Description:  Simvastatin is a member of the statins, a class of cholesterol-lowering drugs whose major potential adverse effect is skeletal muscle toxicity. Symptoms may include muscle pain, muscle degradation (myopathy), or severe muscle damage.

Snacking

Description:  Snacking can be a healthy or unhealthy behavior depending on the food selection. Eating healthy foods in small portions throughout the day has been found in some people to decrease hunger cravings and reduce overall calories, while snacking on junk food can have negative health effects.

Supplements

We have a variety of nutrition supplements based on your individual plan and weight loss/fitness needs.

Some of our brands include:

  • BSN
  • Labrada
  • Luna
  • Clif
  • Isopure
  • Jay Robb
  • Revival

Our physician will work with you to figure out which ones will work best with your genetic makeup.

Sweet Tooth

Description: Craving sweet foods is sometimes described as having a “sweet tooth.” Individuals with a “sweet tooth” tend to have the propensity to eat more sweets throughout the day than the general population.

 

T

Triglycerides (Genetic Risk for Elevated)

Description:  Triglyceride is the technical for fat as it is stored in your body. People with elevated triglycerides are at risk of coronary artery disease and type 2 diabetes. Triglyceride levels can be monitored by the physician.

Triploidy

Triploidy is a rare chromosomal abnormality. Fetuses with Triploidy, or Triploid Syndrome, have an extra set of chromosomes in their cells. One set of chromosomes has 23 chromosomes and is called a haploid set.

Tumor Suppressor Genes

Limit cell growth by monitoring how quickly cells divide into new cells. If the gene is mutated, cells can grow uncontrollably into a tumor. (e.g. BRCA1 and BRCA2 – hereditary breast cancer)

 

 

U

Ultrasound

Ultrasound images have many uses during pregnancy. Early on, they may be used to determine due dates, reveal the presence of twins or other multiples, and rule out ectopic pregnancies. They also are valuable screening tools in helping to detect potential problems, including birth defects, placental issues, breech positioning, and others. Many expectant parents look forward to learning the sex of their babies via ultrasound midway through a pregnancy. And later in pregnancy, doctors can even use ultrasounds to estimate how large a baby is just before delivery.

 

 

V

Venous Thrombosis

Description:  Venous thrombosis (VT) is the formation of a blood clot in the veins that can potentially lead to thromboembolism (i.e., the blocking of a blood vessel by a portion of the clot that has broken away from it). The individual risk of venous thromboembolism (VTE) is determined by a complex interaction of genetic, circumstantial and environmental factors. Risk factors for VT include immobility, surgery, trauma, cancer, hormonal therapy, pregnancy, advanced age and family history.

 

W

Warfarin

Description:  Warfarin is the most frequently used oral anticoagulant worldwide, prescribed for indications such as venous thrombosis, pulmonary embolism, atrial fibrillation and cardiac valve replacement. Warfarin is highly effective, but also has a high incidence of adverse events. Customizing initial warfarin dose based on genetic results may decrease the risk of bleeding complications and may reduce the time required to achieve a stable, therapeutic effect.

Weight Loss – Regain

Description:  Some genetic markers are associated with the tendency to gain weight back after an individual loses weight, while other genetic markers protect a person from weight regain.

Wellness

The state or condition of being in good physical and mental health.

 

X

X-linked Recessive Disorder

is a mode of inheritance in which a mutation in a gene on the X chromosome causes the phenotype to be expressed in males (who are necessarily hemizygous for the gene mutation because they have one X and one Y chromosome) and in females who are homozygous for the gene mutation.

X-linked inheritance means that the gene causing the trait or the disorder is located on the X chromosome. Females have two X chromosomes, while males have one X and one Y chromosome. Carrier females who have only one copy of the mutation do not usually express the phenotype, although differences in X chromosome inactivation can lead to varying degrees of clinical expression in carrier females since some cells will express one X allele and some will express the other. The current estimate of sequenced X-linked genes is 499 and the total including vaguely defined traits is 983.[1]

Some scholars have suggested discontinuing the terms dominant and recessive when referring to X-linked inheritance due to the multiple mechanisms that can result in the expression of X-linked traits in females, which include cell autonomous expression, skewed X-inactivation, clonal expansion, and somatic mosaicism.